Shirou and Sakura
Sakura glared at Shirou, dumbfounded at the stupidity of his comment. Shirou, for a moment, wondered what the problem was, until he heard Irisviel's response. As soon as he did, he frowned deeply, and looked down to the floor, feeling utterly awful for being so insensitive.
"I..I'm sorry", he said, clearly extremely contrite.
He paused for a few moments, and then spoke some more.
"Are you O.... Sorry, sorry, sorry", he said, catching his stupidity this time.
"Shirou, please, just stop talking", Sakura said, rebuking him for his stupidity.
Sakura wasn't angry with him, as such. After all, he was only trying to help. She was more disappointed and annoyed at his stupidity. As a mother, she knew how it would feel if she was told her child was dead, even an alternate version, and she certainly sympathised with Irisviel's plight.
However, despite her sympathy, she had no idea how to react. How do you comfort someone who just learnt that their child was dead? Instead, she simply approached Irisviel, offering to take the woman into a comforting hug if she desired.