Well, I think we do have some decently sized deserts, more to the Southwest and towards California. But I don't think the US would be the last safe haven really, considering how entrenched we are with stuff involving commerce. Really, I think the desert area would likely be more in the Middle East, though that's just my guess. ^_^"
More on the game itself, what was everyone's first route, or what route do you plan on playing when you actually do play?