Yes, but not just Sakura.
the only way to resolve that issue beyond sakura is to fight kirei, whoopie one boss fight difference, imo not worth a whole other route.
Well, and dealing with her "magus" issues more generally.
Not really, particularly given the setting.
Taiga, caster, rider, avenger, Archer (although i see that as more of a secret unlock thing then a route) and ilya, just off the top of my head.
Taiga, how? She's uninvolved in everything.
As for the rest, Ilya was on the original list but is a loli, Rider's issues are "Sakura" (although I guess she could be picked, particularly if it's non-romantic) and Caster is a villain....